赵铁军
发布时间: 2016-10-08 浏览次数: 7741
 

赵铁军,男,1979年生,医学博士,教授,硕士生导师,生物技术系主任。


教育及工作背景:

2012.4—浙江师范大学化学与生命科学学院 教授

2010.4—2012.3 日本学术振兴会(JSPS外国人特别研究员

2006.4—2010.3 日本京都大学医学院 医学博士学位(日本政府奖学金资助)

2002.9—2005.7 南开大学生命科学学院 理学硕士学位

1998.9—2002.7 浙江师范大学生物系 理学学士学位


专业领域:

1.生物化学与分子生物学

2.细胞生物学

3.基础医学


研究方向:

1.成人T细胞白血病发生的分子机制研究

2.抗白血病药物的开发和应用评价

3.肿瘤细胞信号转导与基因调控


主持科研项目:

1.国家自然科学基金面上项目:长链非编码RNA-ANRIL在人类T淋巴细胞白血病1型病毒致癌中的作用及其分子机制研究。(2015-2018

2.国家自然科学基金青年基金项目:人类T淋巴细胞白血病1型病毒HBZ蛋白通过抑制C/EBPalpha信号通路促进肿瘤细胞生长的机制研究。(2013-2015

3.浙江省科技厅公益技术应用研究计划项目:靶向多肽R8-HBAP抑制成人T细胞白血病的机制研究及应用评价。(2015-2017

4.浙江省人力资源和社会保障厅留学人员科技活动择优资助项目:合成多肽TAT-HAAP抑制成人T细胞白血病的分子机制研究。(2013-2014

5.日本学术振兴会科学研究补助金:成人T细胞白血病I型病毒致癌分子机制及其治疗方法的开发。(2010-2012


主要学术论文:

1.Lingling Xu, Xueqing Zhang, Wenzhao Cheng, Yong Wang, Kaining Yi, Zhilong Wang, Yiling Zhang, Linxiang Shao, Tiejun Zhao*. Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription. Retrovirology. 2019, 16: 5. (*corresponding author) (SCI二区,IF=3.478)

2.Kaining Yi, Yiling Zhang, Yong Wang, Zhilong Wang, Mengjia Xie, Zhigang Jin, Tiejun Zhao*. Long noncoding RNA and its role in virus infection and pathogenesis. Frontiers in Bioscience-Landmark. 2019, 24: 777-789. (*corresponding author) (SCI三区,IF=2.497)

3.Zaowen Song, Wencai Wu, Mengyun Chen, Wenzhao Cheng, Juntao Yu, Jinyong Fang, Lingling Xu, Jun-ichirou Yasunaga, Masao Matsuoka, and Tiejun Zhao*. Long noncoding RNA ANRIL supports proliferation of adult T-cell leukemia cells through cooperation with EZH2. Journal of Virology. 2018, 92(24). pii: e00909-18. (*corresponding author) (SCI二区,IF=4.368)

4.Tiejun Zhao*. The Role of HBZ in HTLV-1-Induced Oncogenesis. Viruses. 2016, 8(2). pii: E34. (*corresponding author) (SCI二区,IF=3.761)

5.Tiejun Zhao*, Yorifumi Satou, and Masao Matsuoka. Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice. Archives of Virology. 2014, 159(7): 1849-1856. (*corresponding author) (SCI四区,IF=2.160)

6.Tiejun Zhao*, Aaron Coutts, Lingling Xu, Juntao Yu, Koichi Ohshima, Masao Matsuoka. HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPa signaling. Retrovirology. 2013, 10:159. (*corresponding author) (SCI二区,IF=3.478)

7.Tiejun Zhao, Masao Matsuoka. HBZ and its roles in HTLV-1 oncogenesis. Frontiers in Microbiology. 2012, 3:247. (SCI二区,IF=4.557)

8.Tiejun Zhao, Yorifumi Satou, Kenji Sugata, Patrick L. Green, Takeshi Imamura, Masao Matsuoka. Human T-cell leukemia virus type 1 bZIP factor enhances TGF-beta signaling through p300 coactivator. Blood. 2011;118 (7):1865-1876. (SCI一区,IF=15.132)

9.Tiejun Zhao, Jun-ichirou Yasunaga, Yorifumi Satou, Mitsuyoshi Nakao, Masahiko Takahashi, Masahiro Fujii, Masao Matsuoka. Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB. Blood. 2009;113 (12):2755-2764. (SCI一区,IF=15.132)

10.Michi Miura, Jun-ichirou Yasunaga, Junko Tanabe, Kenji Sugata, Tiejun Zhao, Guangyong Ma, Paola Miyazato, Koichi Ohshima, Akihisa Kaneko, Akino Watanabe, Akatsuki Saito, Hirofumi Akari, Masao Matsuoka. Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology. 2013 Oct 24;10(1):118. (IF=3.417)

11.Yorifumi Satou, Jun-ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L. Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathogens. 7(2):e1001274.doi:10.1371/journal.ppat.1001274. (IF=6.158)

12.Ling Qiao, Zhili Xu, Tiejun Zhao, Zhigang Zhao, Mingxia Shi, Robert Zhao, Lihong Ye, Xiaodong Zhang. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Research. 2008;18(4):500-7. (IF=15.393)

13.Ling Qiao, Zhi-li Xu, Tie-jun Zhao, Li-hong Ye, Xiao-dong Zhang. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters. 2008;269(1):67-77. (IF=6.491)

14.Hong Hui Wang, Hideyuki Tanaka, Xiaoran Qin, Tiejun Zhao, Lihong Ye, Tuyoshi Okagaki, Takeshi Katayama, Akio Nakamura, Ryoki Ishikawa, Sean E. Thatcher, Gary L. Wright, Kazuhiro Kohama. Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells through breaking the interaction between myosin II and actin. Am J Physiol Heart Circ Physiol. 2008;294(5):H2060-8. (IF=3.569)

15.Ling QIAO, Tie-jun ZHAO, Feng-ze WANG, Chang-liang SHAN, Li-hong YE, Xiao-dong ZHANG. NF-kappaB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells. Acta Pharmacol Sin. 2008;29(3):333-40. (IF=3.562)


个人荣誉及获奖情况:

1.获浙江省高校中青年学科带头人(2017年)

2.获浙江师范大学第三届教坛新秀荣誉称号

3.被评为浙江师范大学“三育人”工作先进个人

4.获浙江省高校第八届青年教师教学技能竞赛一等奖


研究室主要成员:

硕士生(3年级):王雍,衣凯宁

硕士生(2年级):王志龙,张熠玲

硕士生(1年级):邹丰,陆皖行


联系方式:

地址:浙江省金华市浙江师范大学化学与生命科学学院10403室,321004

E-mailtjzhao@zjnu.cn


****** 欢迎生物、医学及相关专业的学生加入我们团队!******