朱钢国
发布时间: 2016-03-08 浏览次数: 3634
 

 

朱钢国博士校双龙学者特聘教授

Tel0579-82282640E-mail: gangguo@zjnu.cn

主要经历如下:

19969月-20007月:浙江师范大学化学系,理学学士。

20009月-20057月:中科院上海有机化学研究所,理学博士,导师张兆国教授。

20059月-200710月:师从美国普渡大学诺贝尔化学奖得主Negishi教授博士后研究,完成了spongidepsinhexamethyldocosane等天然产物的全合成。

200711月-200810月:美国印第安纳大学博士后研究。

200812-至今:浙江师范大学化学系任教。现为教授、硕士生导师、化学与生命科学学院副院长,2009年入选浙江省“151”人才第三层次培养对象,2013年入选浙江省高校中青年学科带头人,2016年入选浙江省151人才工程第二层次培养对象、浙江师范大学“双龙学者”特聘教授。已发表Angew. Chem. Int. Ed.Chem. Sci.Org. Lett.Chem. Commun.Adv. Synth. Catal.J. Org. Chem.SCI论文56篇,SCI引用800余次,主要从事过渡金属催化的氟化反应、自由基反应、环异构化反应和生理活性的天然产物全合成研究。

获奖:

12015年浙江省自然科学奖三等奖:杂原子取代炔烃的亲核金属化反应方法学研究(第一完成人);

22012年度浙江省高校优秀科研成果奖一等奖:杂原子取代炔烃的亲核钯化反应方法学研究(第一完成人)。

主持项目:

1、国家自然科学基金面上项目:过渡金属催化的醛直接转化为酮的自由基反应研究(21672191)

2、浙江省公益性技术应用研究计划项目:2-氨基呋喃化学品的催化合成技术研究(2015C31030)

3、国家自然科学基金面上项目:基于1,2-双官能团化烯烃的偶联反应选择性合成多取代烯烃(21172199),已结题;

4、浙江省杰出青年基金:1--1-硫代烯烃的立体选择性合成及其三取代烯烃的构建(LR12B02001) ,已结题;

5、国家自然科学基金青年基金:偶极烯丙基钯的环加成反应研究(20902084) ,已结题;

6、浙江省钱江人才计划项目:抗禽流感药物达菲的合成工艺研究(2010R10016) ,已结题;

7、完成企业横向项目2项。

发表文章

2017

1.Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes, Nie, X.; Cheng, C.; Zhu, G.* Angew. Chem. Int. Ed.2017,56, 1898-1902.

2016

2.Synthesis of (E)-α,β-Unsaturated Carbonyls via Silver-Catalyzed Tandem Epoxide Rearrangement/Intermolecular Carbonyl-Heteroalkyne Metathesis,Zhu, H.; Jin, W.; He, J.; Zhang, Y.*; Zhu, G.* Adv. Synth. Catal. 2016, 358, 3730-3735.

3.Copper-catalyzed cascade annulation between α-bromocarbonyls andbiaryl or (Z)-arylvinylacetylenes enabling a direct synthesis of dibenzocycloheptanes and related compounds, Lu, D.; Wan, Y.; Kong, L.; Zhu, G.*Chem. Commun.2016, 52, 13971-13974.

4.Copper-Catalyzed Trifluoromethylation of Alkenes with Redox-Neutral Remote Amidation of Aldehydes, Cheng, C.; Liu, S.; Lu, D.; Zhu, G.* Org. Lett. 2016, 18, 2852-2855.

5.Copper-catalyzed cascade annulation of unsaturated α-bromocarbonyls with enynals: a facile access to ketones from aldehydes,Che, C.; Huang, Q.; Zheng, H.; Zhu, G.*Chem. Sci. 2016, 7, 4134-4139.

6.Direct access to 2-amino-5-azidomethylfurans through palladium-catalyzed azidative cycloisomerization of homoallenyl amides, Huang, Q.; Zheng, H.; Liu, S.; Kong, L.; Luo, F.*; Zhu, G.* Org. Biomol. Chem. 2016,14, 8557-8563.

7.HOTf-Catalyzed, Solvent-free Oxyarylation of Ynol Ethers and Thioethers, Hu, L.; Cui, Q.; Chen, X.; Tan, Z.*; Zhu, G.* J. Org. Chem. 2016, 81, 4861-4868.

8.Copper-catalyzed coupling of 2-vinyl benzaldehydes with 3-alkenyl 2-bromocarbonyls for the rapid construction of 3,4-cyclopenta-1-tetralones, Zhu, H.; Nie, X.; Huang, Q.; Zhu G.*Tetrahedron Lett.2016, 56, 2331-2335.

9.Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C-H activations, Hu, L.; Chen, X.; Gui, Q.; Tan, Z.*, Zhu, G. Chem. Commun. 2016,52, 6845-6848.

2015

10.A rapid and selective synthesis of α,α-fluorohalo esters via fluorohalogenative or difluorinative hydration of ynol ethers, Hu, L.; Che, C.; Tan, Z.;* Zhu, G.* Chem. Commun. 2015, 51, 16641-16644.

11.Construction of 1-Naphthols via Benzannulation Based on the Reaction of Aryl tert-Butyl Ynol Ethers with Ynamides or Ynol Ethers, Bai, Y.; Yin, J.; Liu, Z.; Zhu, G.* J. Org. Chem. 2015, 80, 10226-10233.

12.Copper-Catalyzed trans-Carbohalogenation of Terminal Alkynes with Functionalized Tertiary Alkyl Halides, Che, C.; Zheng, H.; Zhu, G.* Org. Lett. 2015, 17, 1617-1620.

13.Palladium-Catalyzed Cycloisomerization and Aerobic Oxidative Cycloisomerization of Homoallenyl Amides: A Facile and Divergent Approach to 2-Aminofurans, Cheng, C.; Liu, S.; Zhu, G.* Org. Lett. 2015, 17, 1581-1584.

14.Copper-catalyzed regio- and stereoselective hydroallylation of thioalkynes with allylboronates: a facile and convenient synthesis of 1,4-dienes, Kong, W.; Che, C.; Kong, L.*; Zhu, G.* Tetrahedron Lett.2015, 55, 2780-2782.

15.Copper-Catalyzed β-Selective Borylation of Ynamides: A Facile Access to (E)-β-Alkenylamide Boronates, Bai, Y.*; Zhang, F.; Shen, J.; Luo, F.; Zhu, G.*Asian J. Org. Chem.2015, 4, 626-629 (Dedicated to Prof. Ei-ichi Negishi on the occasion of his 80th birthday)

16.Divergent Synthesis of 2-Aminofurans via Palladium-Catalyzed Acetoxylative, Alkoxylative, and Hydroxylative Cycloisomerization of Homoallenyl Amides, Cheng, C.; Liu, S.; Zhu, G.* J. Org. Chem. 2015, 80, 7604-7612.

2014

17.Palladium-Catalyzed Cross Addition of Terminal Alkynes to Aryl Ynamides: An Unusual trans-Hydroalkynylation Reaction, Liu, G.; Kong, W.; Che, J.; Zhu, G.* Adv. Synth. Catal. 2014, 356, 3314-3318.

18.Preparation of (Z)-α,β-Disubstituted Enamides via Palladium-Catalyzed Addition of Boronic Acids to Ynamides, Yang, Y.; Wang, L.; Zhang, F.; Zhu. G.*J. Org. Chem.2014, 79, 9319-9324.

19.Silver-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Ynol Ethers, Yin, J.; Bai, Y.; Mao, M.; Zhu. G.*J. Org. Chem.2014, 79, 9179-9185.

20.Silver-promoted trans-hydrofluorination of ynamides: a regio- and stereoselective approach to (Z)-α-fluoroenamides, Che, J.; Li, Y.; Zhang, F.; Zheng, R.*; Bai, Y.;Zhu. G.* Tetrahedron Lett. 2014, 55, 6240-6242.

21.Pd-Catalyzed Regio- and Stereoselective Addition of Boronic Acids to Silylacetylenes: A Stereodivergent Assembly of β,β-Disubstituted Alkenyl Silanes and Alkenyl Halides, Kong, W.; Che, C.; Wu, J.; Ma, L.; Zhu, G.*J. Org. Chem. 2014, 79, 5799-5805.

22.Palladium-Catalyzed Hydroarylation, Hydroalkenylation, and Hydrobenzylation of Ynol Ethers with Organohalides: A Regio- and Stereoselective Entry to α,β- and β,β-Disubstituted Alkenyl Ethers, Cui, W.; Ying, J.;Zheng, R.; Cheng, C.; Bai, Y. Zhu, G.* J. Org. Chem. 2014, 79, 3487-3493.

23.An unprecedented Pd-catalyzed trans-addition of boronic acids to ynamides. Yang, Y.; Wang, L.; Zhang, J.; Jin, Y.; Zhu, G.*Chem. Commun.2014, 50, 2347-2349.

24.Synthesis of cis-1,2-dichlorovinylsulfones via Fe-catalyzed regio- and stereoselective addition of sulfonyl chlorides to aromatic chloroalkynes. Wang, L.; Zhu, H.; Che, J.; Yang, Y.*; Zhu, G.*Tetrahedron Lett. 2014, 55,1011-1013.

25.Synthesis of (Z)-1-Thio- and (Z)-2-Thio-1-alkenyl Boronates via Copper-Catalyzed Regiodivergent Hydroboration of Thioacetylenes: An Experimental and Theoretical Study. Zhu, G.*; Kong, W.; Feng, H.; Qian, Z.* J. Org. Chem. 2014, 79, 1786-1795.

26.A regio- and stereoselective entry to (Z)-β-halo alkenyl sulfides and their applications to the access of stereodefined trisubstituted alkenes. Liu, G.; Kong, L.; Shen, J.; Zhu, G.*Org. Biomol. Chem.2014, 12, 2310-2321.

2013

27.Palladium-Catalyzed Direct Alkenylation of 2-Oxazolones: An Entry to 3,4,5-Trisubstituted 2-Oxazolones, Lu, Z.; Luo, F.; Wang, L.; Zhu, G.* J. Org. Chem.2013, 78, 10894-10901.

28.Pd-catalyzed addition of boronic acids to ynol ethers: a highly regio- and stereoselective synthesis of trisubstituted vinyl ethers. Bai, Y.; Yin, J.; Kong, W.; Mao, M.; Zhu, G.*Chem. Commun.2013, 49, 7650-7652.

29.Regioselective and Stereoselective Entry to β,β-Disubstituted Vinyl Ethers via the Sequential Hydroboration/Suzuki–Miyaura Coupling of Ynol Ethers. Cui, W.; Mao, M.; He, Z.; Zhu, G.*J. Org. Chem.2013, 78, 9815-9821.

30.Copper-catalyzed direct thiolation of xanthines and related heterocycles with disulfides. He, Z.; Luo, F.;* Li, Y.; Zhu, G.* Tetrahedron Lett. 2013,54, 5907-5910.

31.An operationally simple approach to (E)-α-halo vinyl sulfides and their applications for accessing stereodefined trisubstituted alkenes. Yang, Z.(本科生); Chen, X.; Kong, W.; Xia, S.; Zheng, R.; Luo, F.; Zhu, G.*Org. Biomol. Chem.2013, 11, 2175-2185.

2012

32.Highly stereoselective synthesis of (Z)-1,2-dihaloalkenes by a Pd-catalyzed hydrohalogenation of alkynyl halides. Zhu, G.*; Chen, D.; Wang, Y.; Zheng, R.Chem. Commun.2012, 48, 5796-5798.

33.Preparation of 3,4,5-Trisubstituted Oxazolones by Pd-Catalyzed Coupling of N-Alkynyl tert-Butyloxycarbamates with Aryl Halides and Related Electrophiles. Lu, Z.; Cui, W.; Xia, S.; Bai, Y.; Luo, F.; Zhu, G.*J. Org. Chem.2012, 77,9871-9877.

34.A Facile Access to 3,5-Disubstituted Oxazolones Featuring a Cu-catalyzed Cyclization of N-Alkynyl tert-Butyl Carbamates. Lu, Z.; Yang, Z.; Cui, W.; Zhu, G.* Chem. Lett.2012, 41, 636-638.

35.Approach to highly functionalized oxazolones by a Pd-catalyzed cyclization of N-alkynyl tert-butyloxycarbamates. Lu, Z.; Xu, X.; Yang, Z.; Kong, L.*; Zhu, G.*Tetrahedron Lett. 2012, 53, 3433-3436.

36.A Facile Method for the Synthesis of 3-Alkyloxindole. Du, T.; Zhu, G.*; Zhou, J.* Lett. Org. Chem.2012, 9, 225-232.

2011

37.Palladium-catalyzed haloallylation of aromatic ynol ethers with allyl chlorides: a highly regio- and stereoselective approach to (1E)-α-chloroenol ethers. Cai, H.(本科生); Yuan, Z.; Zhu, W.; Zhu, G.*Chem. Commun.2011, 47, 8682-8684.

38.Palladium-catalyzed highly regio- and stereoselective synthesis of (1E)- or (1Z)-1,2-dihalo-1,4-dienes via haloallylation of alkynyl halides. Chen, X.; Kong, W.; Cai, H.; Kong, L.; Zhu, G.*Chem. Commun. 2011,47,2164-2166.

39.Palladium-Catalyzed Dienylation of Haloalkynes Using 2,3-Butadienyl Acetates: A Facile Access to (1Z)-1,2-Dihalo-3-vinyl-1,3-dienes. Chen, D.; Chen, X.; Lu, Z.; Cai, H.; Shen, J.; Zhu, G.* Adv. Synth. Catal. 2011, 353, 1474-1478.

40.Synthesis of Multisubstituted Enamides via Pd-Catalyzed Chloroallylation of Ynamides. Lu, Z.; Kong, W.; Yuan, Z.; Zhao, X.; Zhu. G.* J. Org. Chem. 2011, 76, 8524-8529.

41.Palladium-Catalyzed Coupling of Haloalkynes with Allyl Acetate: A Highly Regio- and Stereoselective Synthesis of (Z)-β-Haloenol Acetates.Chen, X.; Chen, D.; Lu, Z.; Kong, L.; Zhu, G.* J. Org. Chem. 2011, 76, 6338-6343.

42.Synthesis of cis-1,2-Dihaloalkenes Featuring Palladium-Catalyzed Coupling of Haloalkynes and α,β-Unsaturated Carbonyls. Chen, D.; Cao, Y.; Yuan, Z.; Cai, H.; Zheng, R.; Kong, L.; Zhu, G.*J. Org. Chem. 2011,76, 4071-4074.

2010

43.Highly efficient and diastereoselective synthesis of 1,3-oxazolidines featuring a palladium-catalyzed cyclization reaction of 2-butene-1,4-diol derivatives and imines. Chen, D.; Chen, X.; Du, T.; Kong, L.; Zheng, R.; Zhen, S.; Wen, Y.; Zhu, G.*Tetrahedron Lett.2010, 51, 5131-5133.

博士及博士后阶段

44.A Tunable Mimics of Pyridoxal-5’-phosphate (PLP) Catalyst for Schiff Base Exchange and Amine Deprotonation. Felten, A.; Zhu, G.; Aron, Z.* Org. Lett.2010, 12, 1099-1101.

45.Efficient and Selective Synthesis of (S,R,R,S,R,S)-4,6,8,10,16,18-Hexamethyldocosane via Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA Reaction). Zhu, G.; Liang, B.; Negishi, E.*Org. Lett.2008, 10, 1099-1101.

46.1,4-Pentenyne as a Five-Carbon Synthon for Efficient and Selective Syntheses of Natural Products Containing 2,4-Dimethyl-1-penten-1,5-ylidene and Related Moieties via Zr-Catalyzed Carboalumination of Alkynes and Alkenes. Zhu, G.; Negishi, E.* Chem. Eur. J.2008, 14, 311-318.

47.Fully Reagent-Controlled Asymmetric Synthesis of (–)-Spongidepsin via the Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA Reaction). Zhu, G.; Negishi, E.* Org. Lett.2007, 9, 2771-2774.

48.Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA)_Lipase-Catalyzed Acetylation Synergy. Huang, Z.; Tan, Z.; Novak, T.; Zhu, G.; Negishi, E.* Adv. Synth. Catal.2007, 349, 539-545.

49.Zirconium-Catalyzed Methylalumination of Heterosubstituted Arylethynes. Factors Affecting the Regio-, Stereo-, and Chemoselectivities. Wang, G.; Zhu, G.; Negishi, E.* J. Organomet. Chem.2007, 692, 4731-4736.

50.Palladium-Catalyzed Cyclization via Carbopalladation and Acylpalladation. Negishi, E.*; Wang, G.; Zhu, G. Topics in Organometallic Chemistry, 2006, 19, 1-48.

51.Transition Metal-Catalyzed Intramolecular Enyne Cyclization Reaction. Zhang, Z.*; Zhu, G.; Tong, X.; Wang, F.; Xie, X.; Wang, J.; Jiang, L. Curr. Org. Chem.2006, 10, 1457-1478.

52.Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,6-Enynes: Reaction Scope and Mechanism. Zhu, G.; Tong, X.; Cheng, J.; Sun, Y.; Li, D.; Zhang, Z.* J. Org. Chem. 2005, 70, 1712-1717.

53.cis-Chloropalladation of 1,6-Enynes. Zhu, G.; Zhang, Z.* J. Org. Chem. 2005, 70, 3339-3341.

54.A Concise Synthesis of 2-Diarylphosphino-20-methoxy-1,10-binaphthalenes (MOPs) by Simple Resolution. Luo, Y.; Wang, F.; Zhu, G.; Zhang, Z.* Tetrahedron Asymmetry 2004, 15, 15-17.

55.Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,2,7-trienes. Zhu, G.; Zhang, Z.* Org. Lett.2004, 6, 4041-4044.

56.Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,6-Enynes. Zhu, G.; Zhang, Z.* Org. Lett., 2003, 5, 3645-3648.

指导学生:

 1、校优秀硕士学位论文:陈东旭(2012)、卢增辉(2013)、崔伟剑(2014)、孔伟(2015)、印靖(2015)、车超(2016)、刘水有(2016)。

2、夏思苑等,杂原子取代炔烃的氢卤化反应研究及其应用,第十三届大学生“挑战杯”竞赛浙江省一等奖、全国二等奖。

授权专利:

1、顺式-1--2-氯代烯烃及其制备方法和应用,朱钢国、陈东旭,专利号:ZL 201210004757.9,授权时间:2013.11.27

2、一种莽草酸的合成方法,朱钢国、崔伟剑、夏思苑、何祖莺,专利号:ZL 201210094437.7,授权时间:2013.11.27

3、一种3,4,5-三取代噁唑-2-酮的合成方法,朱钢国、卢增辉、刘鸽、罗芳、夏思苑,专利号:ZL 201210283568.X,授权时间:2014.11.05

4、一种利用顺式-1--2-氯代烯烃合成维生素A的方法,朱钢国,陈东旭,专利号:ZL 201310350098.9,授权时间:2014.11.05

5、一种替马罗汀的合成方法,朱钢国、李英龙、金雅丽、金发根、吴平、楼益义,专利号:ZL 201310362839.5,授权时间:2015.01.14

6、一种奥司他韦的合成方法,朱钢国、杜思全、章洁妮、程存归,专利号:ZL 201410102788.7,授权时间:2015.05.27