谢建武
发布时间: 2016-03-14 浏览次数: 2475
 

 

谢建武博士,教授

联系方式:xiejw@zjnu.cn

个人简历:

    谢建武博士,教授2004年毕业于广西师范大学,2007年毕业于中国科学院成都有机化学研究所,师从邓金根研究员和四川大学陈应春教授,获得博士学位;20074月,赴日本京都大学并以COE研究员的进行研究,师从竹本佳司(Yoshiji Takemoto)教授;20087月,进入浙江师范大学化学与生命科学学院工作,201012月晋升为教授。目前在国内外学术期刊Angew. Chem. Int. Ed.Chem.Commun.Org. Lett.J. Org. Chem.Tetrahedron Lett.Org. Biomol. Chem.Adv. Synth. Catal.Tetrahedron上发表论文50余篇,论文他引超过600次,单篇他引大于200次;主持国家自然科学基金项目2项,教改重点项目1项,省部级及其他项目多项。先后获得中国科学院院长优秀奖2007)、中国科学院西部学子奖20062007)、“浙江师范大学青年骨干教师”、浙江省新世纪151人才工程第三层次培养人员(2009)、浙江省高等学校中青年学科带头人2013)、浙江省科学技术奖三等奖2013)等荣誉称号。

获奖情况:

1. 中国科学院西部学子奖学金(20062007

2. 中国科学院院长优秀奖(2007

3. 基于羰基化合物高选择性合成杂环化合物的研究;浙江省人民政府;浙江省科学技术奖三等奖;谢建武(排名1/6);2013年。

5. 第六届浙江省大学生化学学科竞赛一等奖,指导教师:谢建武(1/2),2014年。

6. 浙江省第十四届挑战杯一等奖,指导教师:谢建武1/1),2015年。

人才梯队、荣誉:

浙江省新世纪151人才工程第三层次培养人员(2009;

省高校中青年学科带头人(2013;

浙江师范大学优秀青年骨干教师(2008)

研究方向:

1. 新型催化剂的设计与合成及其在不对称合成中的应用

2. 新反应新方法的研究

3. 药物及其中间体合成技术的研发

主持的科研项目:

1. 基于手性胺出发的新型催化剂的合成及应用(浙江省科技厅)

2. 基于1,3-二羰基化合物的串联反应高选择性合成杂环化合物的研究(国家自然科学基金面上项目)

3.新颖手性有机催化剂在不对称催化13-质子迁移和三氟甲基化反应的应用(国家自然科学基金青年基金)

4.有机催化不对称合成光学纯的三氟甲基化合物(浙江省自然科学基金)

5. 有机小分子催化的不对称串联反应研究(浙江师范大学青年基金)

6. 2-羟基吡啶N-氧化物的合成工艺研发浙江野风药业有限公司

7. 2,3-二氢呋喃衍生物的绿色合成工艺技术开发(浙江师范大学)

8.华法林药物的合成工艺研发(兰溪康恒医药化工有限公司)

主持的教改项目:

1. 基于竞赛培养高素质师范类化学人才的研究(教学改革重点项目

论文:

50. X.-N. Ping, P.-S. Wei, X.-Q. Zhu, J.-W. Xie*, Catalyst-Controlled Switch in Diastereoselectivities: Enantioselective Construction of Functionalized 3,4-Dihydro-2H-thiopyrano[2,3-b]quinolines with Three Contiguous Stereocenters, J. Org. Chem. 2017, 82, 2205-2210.

2016

49. X.-Q. Zhu, J.-S. Wu, J.-W. Xie*, Stereoselective Construction of Bi-spirooxindole Frameworks via a Michael Addition/Cyclization and an Unexpected Redox/Oxidative Coupling/Cyclization, Tetrahedron, 2016, 72, 8327-8334.

48.X.-Y. Zhang, Z. Shen, L.-L. Hua, L.-J. Wang, Y.-S. Lin, J.-W. Xie*, H.-L. Cui*, Microwave-assisted organocatalysis: phosphine-mediated Tomita Zipper cyclization affording functionalized spirooxindole, Tetrahedron Lett. 2016, 57, 3790–3794.

47. X.-M. Zeng, J.-W. Xie*, Enantioselective Synthesis of Ring-Fused Spiroannulated 1,2,3-Thiadiazole Derivatives, J. Org. Chem. 2016, 81, 3553–3559.

46. P.-S. Wei, M.-X., Wang, D.-C. Xu and J.-W. Xie*, Synthesis of 2,3-Dihydrothieno(2,3b)quinolines and Thieno(2,3b)-quinolines via an Unexpected Domino Aza-MBH/Alkylation/Aldol Reaction, J. Org. Chem. 2016, 81(3), 1216–1222.

2015

44. X.-Y Zhang, J.-W. Xie* and H.-L. Cui*, Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylation/Alkyne Oxacyclization/Isomerization Cascade Under Microwave Irradiation, Synlett., 2015, 2821-2825.

43. J.-S. Wu*, X. Zhang, Y.-L. Zhang and J.-W. Xie*, Synthesis and antifungal activities of novel polyheterocyclic spirooxindole derivatives, Org. Biomol. Chem., 2015, 13, 4967-4975.

42. W. Chen, R.-Z. Zhang, X.-Y. Lu, and J.-W. Xie, Asymmetric Synthesis of Highly Functionalized Cyclohexa-1,3-dienes via Organocatalyzed One-Pot Three-Component Domino Reaction of Malononitrile with α,β-Unsaturated Imines, J. Braz. Chem. Soc.,2015, 26, 405-410.

41. X.-M. Zeng, C.-Y. Meng, J.-X. Bao, D.-C. Xu, J.-W. Xie*and W.-D. Zhu, Enantioselective Construction of Polyfunctionalized Spiroannulated Dihydrothiophenes via a Formal Thio [3 + 2] Cyclization, J. Org. Chem. 2015, 80, 11521-11528.

2014

38. D.-L. Chen, N. Wang, F.-F. Wang, J.-W. Xie, Y. Zhong, W. Zhu*, J. K. Johnson, and R. Krishna*, Utilizing the Gate-Opening Mechanism in ZIF-7 for Adsorption Discrimination between N2O and CO2, J. Phys. Chem. C, 2014, 118 (31), 17831–17837.

36. P. Sun, C.-Y. Meng, F. Zhou, X.-S. Li, J.-W. Xie,* Organocatalytic Asymmetric One-Pot Sequential Reaction: Synthesis of Highly Substituted Spirocyclohexanepyrazolones with Six Contiguous Stereogenic Carbons, Tetrahedron, 2014, 70, 9330-9336.

35. J.-J. Liang, J.-Y. Pan, D.-C. Xu, J.-W. Xie,*Construction of Polyheterocyclic Spirotetrahydrothiophene Derivatives via Sulfa-Michael/aldol Cascade Reaction, Tetrahedron Lett. 2014, 55, 6335–6338.

34. Z.-K. Fu, J.-Y. Pan, D.-C. Xu, J.-W. Xie,*Organocatalytic Domino Michael/Cyclization Reaction: Efficient Synthesis of Multi-functionalized Tetracyclic Spirooxindoles with Multiple Stereocenters, RSC Advances, 2014,4, 51548 – 51557.

33. R.-Z. Zhang, C.-Y. Meng,J.-W. Xie,* M.-L. Xu and W.-D. Zhu, Base-Catalyzed Domino Michael-Alkylation-Rearrangement: A New Synthetic Route to Functionalized 2,3-Dihydrofurans, Eur. J. Org. Chem., 2014,3104-3107.

32. J.-W. Xie*, M.-L. Xu, R.-Z. Zhang, J.-Y. Pan and W.-D. Zhu*, Organocatalytic Domino Reaction of Electron-Deficient 2,4-Dienes with 2-Halo-1,3-Dicarbonyl Compounds: A Highly Regio- and Stereoselective Approach to Functionalized Five-Membered Carbocycles, Adv. Synth. Catal., 2014, 356, 395-400.

2013

31. Z.-W. Guo, X. Huang, J.-M. Mao, W.-D. Zhu and J.-W. Xie*, Diastereoselective synthesis of polysubstituted ∆1-pyrroline derivatives from in situ generated nitrile ylides, RSC Adv., 2013, 3, 25103-25109.

30. T. Shi, Z. Guo, H. Yu, J.-W. Xie*, Y. Zhong, W. Zhu*Highly Atom-Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst, Adv. Synth. Catal., 2013, 355, 2538-2543.

29. X. Huang, Y.-R. Zhang, X.-S. Li, D.-C. Xu, J.-W. Xie*, Construction of Functionalized Spiro 1,4-Benzoxazine Oxindole Derivatives via Domino Mannich-Alkylation of α-Halocarbonyl Compounds with Imines, Tetrahedron Lett. 2013, 54, 5857-5860.

28. J.-Y. Pan, X.-S. Li, D.-C. Xu and J.-W. Xie*, Synthesis of Chiral 1,2-Dihydronaphtho[2,1-b] furans by Organocatalytic Domino Reactions Catalyzed with Multiple Catalysis, Aust. J. Chem. 2013, 66(11), 1415-1421.

27. Y.-R. Zhang, X. Huang, D.-C. Xu and J.-W. Xie*, Facile Domino Access to Unexpected Alkyl 3-Substituted-2-hydroxy-3,4-dihydro-2H- 1,4-benzoxazine-2-carboxylates, Aust. J. Chem. 2013, 66, 959–962.

2012

26. H. Yu, J.-W. Xie*, Y. Zhong, F. Zhang, W. Zhu*, One-pot synthesis of nitroalkenes via the Henry reaction over aminofunctionalized MIL-101 catalysts, Catalysis Communications, 2012, 29, 101-104.

25.Z.-W. Guo,X.-S. Li, W.-D. Zhu,J.-W. Xie,*Construction of Chiral Multi-functionalized Polyheterocyclic Benzopyran Derivatives by Using an Asymmetric Organocatalytic Domino Reaction, Eur. J. Org. Chem., 2012,6924–6932.

24. Z.-W. Guo, J.-W. Xie,* C. Chen, and W. Zhu,*Asymmetric Catalytic [4 + 1] Annulations Catalyzed by Quinidine: Enantioselective Synthesis of Multi-functionalized Isoxazoline N-Oxides, Org. Biomol. Chem.2012, 10 (42), 8471 - 8477.

23.Y.-R. Zhang, F. Luo,* X.-J. Huang, J.-W. Xie,* Water-Compatible Cascade Reaction: An Efficient Route to Substituted 2,3-Dihydrofurans, Chem. Lett., 2012, 41, 777-779.

22. R. Z. Zhang, D. C. Xu, J. W. Xie*, Efficient Synthesis of 3-Phenylnaphtho[2,3-b]furan-4,9- diones in Water and Their Fluorimetric Study in Solutions, Chin. J. Chem., 2012,30, 1690-1694.

21. Y.-R. Zhang, J.-W. Xie*, X.-J. Huang, W.-D. Zhu*, Construction of Functionalized 2,3-Dihydro-1,4-Benzoxazines via [5 + 1] Annulations of 2-Halo-1,3-Dicarbonyl Compounds with Imines, Org. Biomol. Chem.2012, 10, 6554-6561.

20. T. Wang, X.-C. Hu, X.-J. Huang, X.-Sheng Li, J.-Wu Xie*, Efficient Synthesis of Functionalized 1,2,3-Triazolesby Catalyst-free 1,3-Dipolar Cycloaddition of Nitroalkenes with Sodium Azide, J. Braz. Chem. Soc.,2012, 23, 1119-1123.

19. W. Dong, D. Xu, J. Xie, Aqueous-mediatedMichael Addition of Active MethyleneCompounds with Nitroalkenes, Chin. J. Chem., 2012, 30, 1771-1774.

18. W.-K. Dong, X. Huang, D.-C. Xu*, X.-S. Li and J.-W. Xie*, Total Synthesis of 1-Hydroxydehydroherbarin and Ascomycones A, B, Naphthoquinone Antibiotics, J. Braz. Chem. Soc.,2012, 23, 280-284.

17. P. Li, B.-T. Teng, F.-G. Jin, X.-S. Li, W.-D. Zhu, J.-W. Xie*, Synthesis of Functionalized 2,3-Dihydroisoxazoles by Domino Reactions in Water and Unexpected Ring-Opening Reactions of 2,3-Dihydroisoxazoles, Org. Biomol. Chem., 2012, 10, 244-247.

2011

16. Q.-B. Li, F.-T., Zhou, Z.-G. Liu, X.-F. Li, W.-D. Zhu, J.-W. Xie*, K2CO3-Promoted Domino Reactions: Construction of Functionalized 2,3-Dihydrobenzofurans and Clofibrate Analogues, J. Org. Chem. 2011, 76, 7222-7228.

15. L.-P. Fan, W.-J Yang, D.-C. Xu,X.-S. Li, J.-W. Xie*, Efficient Methods for the Synthesis of Benzopyrano[3,4-c]pyrrolidines by Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Substituted Coumarins, Synth. Comm., 2011, 41, 3376–3384.

14. J.-W. Xie*, P. Li, T. Wang, F.-T. Zhou, Efficient and Mild Synthesis of Functionalized 2,3-Dihydrofuran Derivatives Via Domino Reaction in Water, Tetrahedron Lett. 2011, 52, 2379-2382.

2010

13. L.-P Fan, P. Li, X.-S. Li, D.-C. Xu, M.-M. Ge, W.-D. Zhu, J.-W. Xie*, Facile Domino Access to Chiral Mono-, Bi- and Tricyclic 2,3-Dihydrofurans, J. Org. Chem. 2010, 75, 8716-8719.

12.X. Huang, Y.-H. Wen, F.-T. Zhou, C. Chen, D.-C. Xu, J.-W. Xie*,Organocatalytic and Direct Asymmetric Vinylogous Michael Addition of 3-Cyano-4-Methylcoumarins to alpha, beta-Unsaturated Ketones, Tetrahedron Lett. 2010, 51, 6637-6640.

11. P. Li,L.-L. Luo, X.-S. Li,J.-W. Xie*, A Simple Method for the Synthesis of Functionalized 6-Aryl-6H-Dibenzo[b,d]- pyran Derivatives from 3-Nitro-2H-Chromenes, Tetrahedron, 2010, 66, 7590-7594.

10. X. Huang, P. Li,X.-S. Li, D.-C. Xu, J.-W. Xie*, The Organocatalytic Two-step Synthesis of Diversely Functionalized Tricyclic Tetrazoles, Org. Biomol. Chem., 2010, 8, 4527 - 4529.

9. J.-W. Xie*, L.-P. Fan, H. Su, X.-S. Li, D.-C. Xu, Efficient Kinetic Resolution of Racemic 3-Nitro-2H-Chromene Derivatives Catalyzed by Takemoto’s Organocatalyst, Org. Biomol. Chem.,2010, 8, 2177-2122.

2009

8. J.-W. Xie*, X. Huang, L.-P. Fan, D.-C. Xu, X.-S. Li, H. Su, Y.-H. Wen, “Efficient Method forthe Synthesis of Optically Active 2-Amino-2-Chromene Derivatives via One-Pot Tandem Reaction”, Adv. Synth. Catal., 2009, 351, 3077-3082.

7. J.-W. Xie*, Z. Wang , W.-J. Yang , L.-C. Kong , D.-C. Xu, Efficient Method for the Synthesis of Functionalized Pyrazoles by Catalyst-Free One-Pot Tandem Reaction of Nitroalkenes withEthyl Diazoacetate, Org. Biomol. Chem.,2009, 7, 4352 – 4354.

2006-2008

6. J.-W. Xie, K. Yoshida, K. Takasu, and Y. Takemoto, Thiourea-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Azomethine Ylides with Nitroolefins, Tetrahedron Lett. 2008, 49, 6910-6913.

5. T.-R. Kang, J.-W.Xie, W. Du, X. Feng, Y.-C. Chen, Stereoselective desymmetrisation of prochiral a,a-dicyanoalkenes via domino Michael–Michael addition reactions, Org .Biomol. Chem., 2008, 2673-2675.

4. J.-W. Xie, L. Yue, W. Chen, W. Du, J. Zhu, J.-G. Deng*, and Y.-C. Chen*, Highly Enantioselective Michael Addition of Cyclic 1,3-Dicarbonyl Compounds to, α,β-Unsaturated Ketones, Org. Lett., 2007, 9, 413-415.

3. Z.-J. Wu, S.-W. Luo, J.-W. Xie, X.-Y. Xu, D.-M. Fang, and G.-L. Zhang*, Study of Michael-Michael-retro Michael Addition Catalyzed by9-Amino-9-deoxyepiquinine Using ESI-MS, J. Am. Soc. Spectron, 2007, 18, 2074-2080.

2. J.-W. Xie, W. Chen, R. Li, M. Zeng, W. Du, L. Yue, Y.-C. Chen*, Y. Wu, J. Zhu, and J.-G. Deng*, Highly Asymmetric Michael Addition to a,β-Unsaturated Ketones Catalyzed by 9-Amino-9-deoxyepiquinine, Angew. Chem. Int. Ed,2007, 46, 389-392; Angew. Chem. 2007, 119, 393-396.

1. J.-W. Xie, L. Yue, D. Xue, X.-L.Ma, Y.-C. Chen*, Y. Wu, J. Zhu, and J.-G. Deng*, Organocatalytic and Direct Asymmetric Vinylogous Michael Addition of α,α- Dicyan-oolefins to α,β-Unsaturated Aldehyde, Chem. Commun., 2006, 1563-1565.

授权专利:

4. 手性的1,4-二氢吡喃(2,3-c)吡唑衍生物及其合成方法和应用,谢建武、孙平,专利号:ZL 201410115142.2.

3. 4,5-二羟基-3-H-[呋喃-2,3-吲哚]-2-酮衍生物及其合成方法和应用,谢建武、张雪,专利号:ZL201410026948.4.

2. 一种具有抗菌活性的螺[萘满酮-四氢噻吩]衍生物的合成及抗菌活性研究,谢建武、潘金芸,专利号:ZL201410173109.5.

1. 3-羟基-2,3-二氢苯并呋喃衍生物及其合成方法和应用,谢建武,专利号:ZL201110160447.1.